Having your own site to sell gently used handbags is probably going to be a really, really difficult endeavor for what its worth. It will be hard to get enough eyeballs/visitors on those bags to generate enough sales to make you any meaningful income (it’s an incredibly small niche and almost too specific in nature). Not to deter you from the idea completely but you’ll need to commit to several years of patience to really hit a home run in that field.
One of the cool things about Google AdSense is that it's so easy to get set up. If you have a blog or website, you can sign up for a free Google AdSense Account. From there, Google will give you a unique code that you will paste onto your website. Google takes it from there, tracking your page views, traffic, and earnings on your behalf. There is no upkeep or maintenance to get this thing going, which makes it a no-brainer if you have a website already.